Obesity and Multiple Sclerosis: A Mendelian Randomization Study.

observational studies have reported an association between obesity, as measured by an increase in body mass index (BMI), in early adulthood and the risk of multiple sclerosis (MS). However, the potential bias introduced by confounding and reverse causation may have influenced these findings. Therefore, we chose to do a Mendelian randomization (MR) analysis to evaluate whether increased BMI was associated with increased genetic risk of MS.


Using the approach MR two samples, we use a statistical summary of the Genetic Investigation of Anthropometric Traits (GIANT) consortium and the Consortium of MS Genetics International (IMSGC), the study of genome-wide association site for BMI and MS, respectively (GIANT: n = 322 105; IMSGC: n = 14 498 cases and 24 091 controls). Seventy-one-nucleotide polymorphisms (SNPs) whose genome was significant (p <5 x 10-8) for BMI at GIANT (n = 322 105) and investigated for their association with the risk of MS in IMSGC.

The effect of each SNP in MS weighed against the effect on BMI, and estimates compiled to provide a summary measure of the effect of increased BMI on the risk of MS. Our results suggest that increased BMI affects MS susceptibility, where 1 standard deviation increase in genetically determined BMI (kg / m2) increased likelihood of MS by 41% (odds ratio [OR]: 1.41, 95% CI 1.20 to 1 , 66, p = 2.7 x 10-5, I2 = 0%, 95% CI 0-29). A sensitivity analysis, including MR-Egger regression and weighted median approach provided no evidence of pleiotropic effects. The main limitation of the study is that, while this sensitivity analysis reduces the likelihood that pleiotropy influenced our results, the rest of pleiotropy is difficult to exclude completely.


BMI is associated with an elevated genetic risk of MS, providing evidence for the causal role of obesity in MS etiology. While obesity has been associated with a lot of late-life outcomes, these findings suggest important consequence of childhood and / or early adulthood obesity

DFNB59 siRNA

20-abx914044
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

DFNB31 siRNA

20-abx901477
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

DFNB59 (Myc-DDK-tagged)-Human deafness, autosomal recessive 59 (DFNB59)

RC212618 10 µg Ask for price

Dfnb59 (GFP-tagged) - Mouse deafness autosomal recessive 59 (human) (Dfnb59), (10ug)

MG218967 10 µg Ask for price

Dfnb59 (untagged) - Mouse deafness, autosomal recessive 59 (human) (Dfnb59), (10ug)

MC214709 10 µg Ask for price

Dfnb59 (Myc-DDK-tagged) - Mouse deafness, autosomal recessive 59 (human) (Dfnb59)

MR218967 10 µg Ask for price

DFNB59 Antibody

E307612 200ul
EUR 275
Description: Available in various conjugation types.

Lenti ORF particles, DFNB59 (Myc-DDK tagged) - Human deafness, autosomal recessive 59 (DFNB59), 200ul, >10^7 TU/mL

RC212618L3V 200 µl Ask for price

Lenti ORF particles, DFNB59 (mGFP-tagged) - Human deafness, autosomal recessive 59 (DFNB59), 200ul, >10^7 TU/mL

RC212618L4V 200 µl Ask for price

DFNB31 ELISA KIT|Human

EF004837 96 Tests
EUR 826.8

Lenti ORF clone of Dfnb59 (mGFP-tagged) - Mouse deafness, autosomal recessive 59 (human) (Dfnb59)

MR218967L4 10 µg Ask for price

Lenti ORF particles, Dfnb59 (GFP-tagged) - Mouse deafness, autosomal recessive 59 (human) (Dfnb59), 200ul, >10^7 TU/mL

MR218967L4V 200 µl Ask for price

Dfnb31 ORF Vector (Rat) (pORF)

ORF065974 1.0 ug DNA
EUR 607.2

Lenti ORF clone of Dfnb59 (Myc-DDK-tagged) - Mouse deafness, autosomal recessive 59 (human) (Dfnb59)

MR218967L3 10 µg Ask for price

DFNB31 (GFP-tagged) - Human deafness, autosomal recessive 31 (DFNB31), transcript variant 2

RG213282 10 µg Ask for price

DFNB31 (GFP-tagged) - Human deafness, autosomal recessive 31 (DFNB31), transcript variant 1

RG220471 10 µg Ask for price

DFNB31 (GFP-tagged) - Human deafness, autosomal recessive 31 (DFNB31), transcript variant 3

RG230579 10 µg Ask for price

DFNB31 (untagged)-Human deafness, autosomal recessive 31 (DFNB31), transcript variant 1

SC304310 10 µg Ask for price

DFNB31 (untagged)-Human deafness autosomal recessive 31 (DFNB31) transcript variant 3

SC329217 10 µg Ask for price

DFNB31 (untagged)-Human deafness, autosomal recessive 31 (DFNB31), transcript variant 2

SC316062 10 µg Ask for price

Lenti ORF particles, Dfnb59 (Myc-DDK-tagged) - Mouse deafness, autosomal recessive 59 (human) (Dfnb59), 200ul, >10^7 TU/mL

MR218967L3V 200 µl Ask for price

Rat DFNB31 shRNA Plasmid

20-abx989762
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

DFNB31 (Center) Rabbit pAb

E2611472 100ul
EUR 225
Description: Available in various conjugation types.

Rat Whirlin (DFNB31) ELISA Kit

abx391201-96tests 96 tests
EUR 1093.2

DFNB59 ORF Vector (Human) (pORF)

ORF012836 1.0 ug DNA
EUR 424.8

DFNB13 ORF Vector (Human) (pORF)

ORF018250 1.0 ug DNA Ask for price

DFNB14 ORF Vector (Human) (pORF)

ORF018251 1.0 ug DNA Ask for price

DFNB17 ORF Vector (Human) (pORF)

ORF018252 1.0 ug DNA Ask for price

DFNB19 ORF Vector (Human) (pORF)

ORF018253 1.0 ug DNA Ask for price

DFNB20 ORF Vector (Human) (pORF)

ORF018254 1.0 ug DNA Ask for price

DFNB26 ORF Vector (Human) (pORF)

ORF018255 1.0 ug DNA Ask for price

DFNB27 ORF Vector (Human) (pORF)

ORF018256 1.0 ug DNA Ask for price

DFNB31 ORF Vector (Human) (pORF)

ORF018257 1.0 ug DNA
EUR 486

DFNB32 ORF Vector (Human) (pORF)

ORF018258 1.0 ug DNA Ask for price

DFNB33 ORF Vector (Human) (pORF)

ORF018259 1.0 ug DNA Ask for price

DFNB34 ORF Vector (Human) (pORF)

ORF018260 1.0 ug DNA Ask for price

DFNB38 ORF Vector (Human) (pORF)

ORF018261 1.0 ug DNA Ask for price

DFNB40 ORF Vector (Human) (pORF)

ORF018262 1.0 ug DNA Ask for price

DFNB43 ORF Vector (Human) (pORF)

ORF018263 1.0 ug DNA Ask for price

DFNB44 ORF Vector (Human) (pORF)

ORF018264 1.0 ug DNA Ask for price

DFNB45 ORF Vector (Human) (pORF)

ORF018265 1.0 ug DNA Ask for price

DFNB46 ORF Vector (Human) (pORF)

ORF018266 1.0 ug DNA Ask for price

DFNB47 ORF Vector (Human) (pORF)

ORF018267 1.0 ug DNA Ask for price

DFNB48 ORF Vector (Human) (pORF)

ORF018268 1.0 ug DNA Ask for price

DFNB50 ORF Vector (Human) (pORF)

ORF018270 1.0 ug DNA Ask for price

DFNB51 ORF Vector (Human) (pORF)

ORF018271 1.0 ug DNA Ask for price

DFNB54 ORF Vector (Human) (pORF)

ORF018272 1.0 ug DNA Ask for price

DFNB55 ORF Vector (Human) (pORF)

ORF018273 1.0 ug DNA Ask for price

DFNB56 ORF Vector (Human) (pORF)

ORF018274 1.0 ug DNA Ask for price

DFNB57 ORF Vector (Human) (pORF)

ORF018275 1.0 ug DNA Ask for price

DFNB58 ORF Vector (Human) (pORF)

ORF018276 1.0 ug DNA Ask for price

DFNB60 ORF Vector (Human) (pORF)

ORF018277 1.0 ug DNA Ask for price

DFNB62 ORF Vector (Human) (pORF)

ORF018278 1.0 ug DNA Ask for price

DFNB65 ORF Vector (Human) (pORF)

ORF018279 1.0 ug DNA Ask for price

DFNB66 ORF Vector (Human) (pORF)

ORF018280 1.0 ug DNA Ask for price

DFNB68 ORF Vector (Human) (pORF)

ORF018281 1.0 ug DNA Ask for price

DFNB69 ORF Vector (Human) (pORF)

ORF018282 1.0 ug DNA Ask for price

DFNB70 ORF Vector (Human) (pORF)

ORF018283 1.0 ug DNA Ask for price

DFNB71 ORF Vector (Human) (pORF)

ORF018284 1.0 ug DNA Ask for price

DFNB75 ORF Vector (Human) (pORF)

ORF018285 1.0 ug DNA Ask for price

DFNB76 ORF Vector (Human) (pORF)

ORF018286 1.0 ug DNA Ask for price

DFNB78 ORF Vector (Human) (pORF)

ORF018287 1.0 ug DNA Ask for price

DFNB80 ORF Vector (Human) (pORF)

ORF018288 1.0 ug DNA Ask for price

DFNB81 ORF Vector (Human) (pORF)

ORF018289 1.0 ug DNA Ask for price

DFNB83 ORF Vector (Human) (pORF)

ORF018290 1.0 ug DNA Ask for price

DFNB85 ORF Vector (Human) (pORF)

ORF018291 1.0 ug DNA Ask for price

DFNB86 ORF Vector (Human) (pORF)

ORF018292 1.0 ug DNA Ask for price

DFNB87 ORF Vector (Human) (pORF)

ORF018293 1.0 ug DNA Ask for price

DFNB88 ORF Vector (Human) (pORF)

ORF018294 1.0 ug DNA Ask for price

DFNB89 ORF Vector (Human) (pORF)

ORF018295 1.0 ug DNA Ask for price

DFNB90 ORF Vector (Human) (pORF)

ORF018296 1.0 ug DNA Ask for price

DFNB92 ORF Vector (Human) (pORF)

ORF018297 1.0 ug DNA Ask for price

DFNB93 ORF Vector (Human) (pORF)

ORF018298 1.0 ug DNA Ask for price

DFNB94 ORF Vector (Human) (pORF)

ORF018299 1.0 ug DNA Ask for price

DFNB96 ORF Vector (Human) (pORF)

ORF018300 1.0 ug DNA Ask for price

Dfnb59 ORF Vector (Mouse) (pORF)

ORF042946 1.0 ug DNA
EUR 607.2

Dfnb31 3'UTR GFP Stable Cell Line

TU253361 1.0 ml Ask for price

Dfnb59 3'UTR GFP Stable Cell Line

TU253362 1.0 ml Ask for price

Dfnb59 3'UTR GFP Stable Cell Line

TU155089 1.0 ml Ask for price

DFNB13 3'UTR GFP Stable Cell Line

TU055881 1.0 ml
EUR 2799.6

DFNB14 3'UTR GFP Stable Cell Line

TU055882 1.0 ml
EUR 2799.6

DFNB15 3'UTR GFP Stable Cell Line

TU055883 1.0 ml
EUR 2799.6

DFNB17 3'UTR GFP Stable Cell Line

TU055884 1.0 ml
EUR 2799.6

DFNB19 3'UTR GFP Stable Cell Line

TU055885 1.0 ml
EUR 2799.6

DFNB20 3'UTR GFP Stable Cell Line

TU055886 1.0 ml
EUR 2799.6

DFNB26 3'UTR GFP Stable Cell Line

TU055887 1.0 ml
EUR 2799.6

DFNB27 3'UTR GFP Stable Cell Line

TU055888 1.0 ml
EUR 2799.6

DFNB31 3'UTR GFP Stable Cell Line

TU055889 1.0 ml
EUR 1672.8

DFNB32 3'UTR GFP Stable Cell Line

TU055890 1.0 ml
EUR 2799.6

DFNB33 3'UTR GFP Stable Cell Line

TU055891 1.0 ml
EUR 2799.6

DFNB34 3'UTR GFP Stable Cell Line

TU055892 1.0 ml
EUR 2799.6

DFNB38 3'UTR GFP Stable Cell Line

TU055893 1.0 ml
EUR 2799.6

DFNB40 3'UTR GFP Stable Cell Line

TU055894 1.0 ml
EUR 2799.6

DFNB42 3'UTR GFP Stable Cell Line

TU055895 1.0 ml
EUR 2799.6

DFNB43 3'UTR GFP Stable Cell Line

TU055896 1.0 ml
EUR 2799.6

DFNB44 3'UTR GFP Stable Cell Line

TU055897 1.0 ml
EUR 2799.6

DFNB45 3'UTR GFP Stable Cell Line

TU055898 1.0 ml
EUR 2799.6

DFNB46 3'UTR GFP Stable Cell Line

TU055899 1.0 ml
EUR 2799.6

DFNB47 3'UTR GFP Stable Cell Line

TU055900 1.0 ml
EUR 2799.6

DFNB48 3'UTR GFP Stable Cell Line

TU055901 1.0 ml
EUR 2799.6

DFNB50 3'UTR GFP Stable Cell Line

TU055902 1.0 ml
EUR 2799.6

DFNB51 3'UTR GFP Stable Cell Line

TU055903 1.0 ml
EUR 2799.6

DFNB54 3'UTR GFP Stable Cell Line

TU055904 1.0 ml
EUR 2799.6

DFNB55 3'UTR GFP Stable Cell Line

TU055905 1.0 ml
EUR 2799.6

DFNB56 3'UTR GFP Stable Cell Line

TU055906 1.0 ml
EUR 2799.6

DFNB57 3'UTR GFP Stable Cell Line

TU055907 1.0 ml
EUR 2799.6

DFNB58 3'UTR GFP Stable Cell Line

TU055908 1.0 ml
EUR 2799.6

DFNB59 3'UTR GFP Stable Cell Line

TU055909 1.0 ml
EUR 1825.2

DFNB60 3'UTR GFP Stable Cell Line

TU055910 1.0 ml
EUR 2799.6

DFNB62 3'UTR GFP Stable Cell Line

TU055911 1.0 ml
EUR 2799.6

DFNB65 3'UTR GFP Stable Cell Line

TU055912 1.0 ml
EUR 2799.6

DFNB66 3'UTR GFP Stable Cell Line

TU055913 1.0 ml
EUR 2799.6

DFNB68 3'UTR GFP Stable Cell Line

TU055914 1.0 ml
EUR 2799.6

DFNB69 3'UTR GFP Stable Cell Line

TU055915 1.0 ml
EUR 2799.6

DFNB70 3'UTR GFP Stable Cell Line

TU055916 1.0 ml
EUR 2799.6

DFNB71 3'UTR GFP Stable Cell Line

TU055917 1.0 ml
EUR 2799.6

DFNB72 3'UTR GFP Stable Cell Line

TU055918 1.0 ml
EUR 2799.6

DFNB74 3'UTR GFP Stable Cell Line

TU055919 1.0 ml
EUR 2799.6

DFNB75 3'UTR GFP Stable Cell Line

TU055920 1.0 ml
EUR 2799.6

DFNB76 3'UTR GFP Stable Cell Line

TU055921 1.0 ml
EUR 2799.6

DFNB78 3'UTR GFP Stable Cell Line

TU055922 1.0 ml
EUR 2799.6

DFNB80 3'UTR GFP Stable Cell Line

TU055923 1.0 ml
EUR 2799.6

DFNB81 3'UTR GFP Stable Cell Line

TU055924 1.0 ml
EUR 2799.6

DFNB82 3'UTR GFP Stable Cell Line

TU055925 1.0 ml
EUR 2799.6

DFNB83 3'UTR GFP Stable Cell Line

TU055926 1.0 ml
EUR 2799.6

DFNB85 3'UTR GFP Stable Cell Line

TU055927 1.0 ml
EUR 2799.6

DFNB86 3'UTR GFP Stable Cell Line

TU055928 1.0 ml
EUR 2799.6

DFNB87 3'UTR GFP Stable Cell Line

TU055929 1.0 ml
EUR 2799.6

DFNB88 3'UTR GFP Stable Cell Line

TU055930 1.0 ml
EUR 2799.6

DFNB92 3'UTR GFP Stable Cell Line

TU055931 1.0 ml
EUR 2799.6

DFNB94 3'UTR GFP Stable Cell Line

TU055932 1.0 ml
EUR 2799.6

DFNB31 (Myc-DDK-tagged)-Human deafness, autosomal recessive 31 (DFNB31), transcript variant 2

RC213282 10 µg Ask for price

DFNB31 (Myc-DDK-tagged)-Human deafness, autosomal recessive 31 (DFNB31), transcript variant 1

RC220471 10 µg Ask for price

DFNB31 (Myc-DDK-tagged)-Human deafness, autosomal recessive 31 (DFNB31), transcript variant 3

RC230579 10 µg Ask for price

Human DFNB31 shRNA Plasmid

20-abx958549
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse DFNB31 shRNA Plasmid

20-abx978020
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Whirlin (DFNB31) Antibody

abx026092-400ul 400 ul
EUR 627.6

Whirlin (DFNB31) Antibody

abx026092-80l 80 µl
EUR 343.2

Human DFNB59 shRNA Plasmid

20-abx968369
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse Whirlin (DFNB31) ELISA Kit

abx389011-96tests 96 tests
EUR 1093.2

Human Whirlin (DFNB31) ELISA Kit

abx384777-96tests 96 tests
EUR 1093.2

Human DFNB31 knockout cell line

ABC-KH4139 1 vial Ask for price
Description: Human DFNB31 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human DFNB59 knockout cell line

ABC-KH4140 1 vial Ask for price
Description: Human DFNB59 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Lenti-ORF clone of DFNB31 (Myc-DDK-tagged)-Human deafness, autosomal recessive 31 (DFNB31), transcript variant 2

RC213282L3 10 µg Ask for price

Lenti-ORF clone of DFNB31 (mGFP-tagged)-Human deafness, autosomal recessive 31 (DFNB31), transcript variant 2

RC213282L4 10 µg Ask for price

Lenti-ORF clone of DFNB31 (Myc-DDK-tagged)-Human deafness, autosomal recessive 31 (DFNB31), transcript variant 3

RC230579L3 10 µg Ask for price

Lenti-ORF clone of DFNB31 (mGFP-tagged)-Human deafness, autosomal recessive 31 (DFNB31), transcript variant 3

RC230579L4 10 µg Ask for price

Dfnb31 ELISA Kit| Rat Whirlin ELISA Kit

EF018555 96 Tests
EUR 826.8

DFNB31 Protein Vector (Rat) (pPM-C-HA)

PV263896 500 ng
EUR 1399.2

Human DFNB31 knockdown cell line

ABC-KD4139 1 vial Ask for price
Description: Human DFNB31 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human DFNB59 knockdown cell line

ABC-KD4140 1 vial Ask for price
Description: Human DFNB59 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

DFNB31 Protein Vector (Rat) (pPB-C-His)

PV263894 500 ng
EUR 1399.2

DFNB31 Protein Vector (Rat) (pPB-N-His)

PV263895 500 ng
EUR 1399.2

DFNB31 Protein Vector (Rat) (pPM-C-His)

PV263897 500 ng
EUR 1399.2

Lenti ORF particles, DFNB31 (Myc-DDK-tagged)-Human deafness, autosomal recessive 31 (DFNB31), transcript variant 2, 200ul, >10^7 TU/mL

RC213282L3V 200 µl Ask for price

Lenti ORF particles, DFNB31 (mGFP-tagged)-Human deafness, autosomal recessive 31 (DFNB31), transcript variant 2, 200ul, >10^7 TU/mL

RC213282L4V 200 µl Ask for price

Lenti ORF particles, DFNB31 (Myc-DDK tagged) - Human deafness, autosomal recessive 31 (DFNB31), transcript variant 1, 200ul, >10^7 TU/mL

RC220471L3V 200 µl Ask for price

Lenti ORF particles, DFNB31 (mGFP-tagged) - Human deafness, autosomal recessive 31 (DFNB31), transcript variant 1, 200ul, >10^7 TU/mL

RC220471L4V 200 µl Ask for price

Lenti ORF particles, DFNB31 (Myc-DDK-tagged)-Human deafness, autosomal recessive 31 (DFNB31), transcript variant 3, 200ul, >10^7 TU/mL

RC230579L3V 200 µl Ask for price

Lenti ORF particles, DFNB31 (mGFP-tagged)-Human deafness, autosomal recessive 31 (DFNB31), transcript variant 3, 200ul, >10^7 TU/mL

RC230579L4V 200 µl Ask for price

DFNB59 Protein Vector (Human) (pPM-C-HA)

PV051343 500 ng
EUR 577.2

Dfnb31 ELISA Kit| Mouse Whirlin ELISA Kit

EF014640 96 Tests
EUR 826.8

DFNB59 Protein Vector (Mouse) (pPM-C-HA)

PV171784 500 ng
EUR 723.6

DFNB13 Protein Vector (Human) (pPM-C-HA)

PV072999 500 ng Ask for price

DFNB14 Protein Vector (Human) (pPM-C-HA)

PV073003 500 ng Ask for price

DFNB17 Protein Vector (Human) (pPM-C-HA)

PV073007 500 ng Ask for price

DFNB19 Protein Vector (Human) (pPM-C-HA)

PV073011 500 ng Ask for price

DFNB20 Protein Vector (Human) (pPM-C-HA)

PV073015 500 ng Ask for price

DFNB26 Protein Vector (Human) (pPM-C-HA)

PV073019 500 ng Ask for price

DFNB27 Protein Vector (Human) (pPM-C-HA)

PV073023 500 ng Ask for price

DFNB31 Protein Vector (Human) (pPM-C-HA)

PV073027 500 ng
EUR 973.2

DFNB32 Protein Vector (Human) (pPM-C-HA)

PV073031 500 ng Ask for price

DFNB33 Protein Vector (Human) (pPM-C-HA)

PV073035 500 ng Ask for price

DFNB34 Protein Vector (Human) (pPM-C-HA)

PV073039 500 ng Ask for price

DFNB38 Protein Vector (Human) (pPM-C-HA)

PV073043 500 ng Ask for price

DFNB40 Protein Vector (Human) (pPM-C-HA)

PV073047 500 ng Ask for price

DFNB43 Protein Vector (Human) (pPM-C-HA)

PV073051 500 ng Ask for price

DFNB44 Protein Vector (Human) (pPM-C-HA)

PV073055 500 ng Ask for price

DFNB45 Protein Vector (Human) (pPM-C-HA)

PV073059 500 ng Ask for price

DFNB46 Protein Vector (Human) (pPM-C-HA)

PV073063 500 ng Ask for price

DFNB47 Protein Vector (Human) (pPM-C-HA)

PV073067 500 ng Ask for price

DFNB48 Protein Vector (Human) (pPM-C-HA)

PV073071 500 ng Ask for price

DFNB50 Protein Vector (Human) (pPM-C-HA)

PV073079 500 ng Ask for price

DFNB51 Protein Vector (Human) (pPM-C-HA)

PV073083 500 ng Ask for price

DFNB54 Protein Vector (Human) (pPM-C-HA)

PV073087 500 ng Ask for price

DFNB55 Protein Vector (Human) (pPM-C-HA)

PV073091 500 ng Ask for price
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