in a recent study on some sclerosis (MS), we observed the effects of the additive and epistatic interactions between variants of four genes were assembled to induce T-cell hyperactivity with change Asn- (N ) -linked protein glycosylation: namely, Golgi enzymes MGAT1, cytotoxic T-lymphocyte antigen 4 (CTLA-4), interleukin-2 receptor-α (IL2RA) and interleukin-7 receptor-α (IL7RA). As CTLA-4, IL2RA and IL7RA variants associated with type 1 diabetes (T1D), we examined for joint effects on T1D.
Employing logistic regression conditional new family-based data sets, the effects of epistatic and additive were observed using 1423 some x family of Type 1 Diabetes genetically The Consortium collection data. The IL2RA and IL7RA variant has a univariate relationship in MS and T1D, while MGAT1 and CTLA-4 variants are associated with only MS or T1D, respectively. However, similar to MS, MGAT1 haplotype variant interacts with CTLA4 (P = 0.03), and the combination IL2RA and IL7RA (P = 0.01). The combined effect of MGAT1, CTLA4, IL2RA, IL7RA and two interactions using the some Conditional logistic regression was statistically significant (P <5 × 10 (-10)).
The MGAT1-CTLA-4 interaction is repeated (P = 0.01) in 179 families trio of Genetics of Kidneys in Diabetes study. These data are consistent with the N-glycosylation defects of T cells contribute to the pathogenesis of T1D.
DFHBI |
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MBS5764668-50mg | MyBiosource | 50mg | EUR 385 |
DFHBI |
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MBS5764668-5mg | MyBiosource | 5mg | EUR 150 |
DFHBI |
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MBS3844201-100mg | MyBiosource | 100mg | EUR 800 |
DFHBI |
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MBS3844201-10mg | MyBiosource | 10mg | EUR 200 |
DFHBI |
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MBS3844201-50mg | MyBiosource | 50mg | EUR 430 |
DFHBI |
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MBS3844201-5mg | MyBiosource | 5mg | EUR 155 |
DFHBI |
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MBS3844201-5x100mg | MyBiosource | 5x100mg | EUR 3600 |
DFHBI |
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T15106-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: DFHBI |
DFHBI |
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T15106-1g | TargetMol Chemicals | 1g | Ask for price |
Description: DFHBI |
DFHBI |
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T15106-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: DFHBI |
DFHBI |
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T15106-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: DFHBI |
DFHBI |
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T15106-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: DFHBI |
DFHBI-1T |
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HY-110251 | MedChemExpress | 10 mg | EUR 703.47 |
Description: DFHBI-1T is a membrane-permeable RNA aptamers-activated fluorescence probe (ex/em=472 nm/507 nm). DFHBI-1T binds to RNA aptamers (Spinach, Spinach2, iSpinach, and Broccoli) and causes specific fluorescence and lower background fluorescence. DFHBI-1T is used to image RNA in live cells[1][2]. |
DFHBI-2T |
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HY-110251A | MedChemExpress | 10 mg | EUR 2597.44 |
Description: DFHBI-2T is a membrane-permeable RNA aptamers-activated fluorescence probe (ex/em=500 nm/523 nm). DFHBI-2T is used to image RNA in live cells[1][2]. |
DFHBI-1T |
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MBS5781025-100mg | MyBiosource | 100(mg | EUR 1155 |
DFHBI-1T |
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MBS5781025-5x100mg | MyBiosource | 5x100mg | EUR 5055 |
DFHBI-2T |
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MBS5799572-10mg | MyBiosource | 10(mg | EUR 965 |
DFHBI-2T |
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MBS5799572-25mg | MyBiosource | 25mg | EUR 1795 |
DFHBI-2T |
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MBS5799572-5x25mg | MyBiosource | 5x25(mg | EUR 7925 |
DFHBI-2T |
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T39022-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: DFHBI-2T |
DFHBI-2T |
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T39022-1g | TargetMol Chemicals | 1g | Ask for price |
Description: DFHBI-2T |
DFHBI-2T |
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T39022-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: DFHBI-2T |
DFHBI-2T |
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T39022-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: DFHBI-2T |
DFHBI-2T |
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T39022-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: DFHBI-2T |
DFHBI-1T |
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T31408-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: DFHBI-1T |
DFHBI-1T |
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T31408-1g | TargetMol Chemicals | 1g | Ask for price |
Description: DFHBI-1T |
DFHBI-1T |
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T31408-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: DFHBI-1T |
DFHBI-1T |
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T31408-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: DFHBI-1T |
DFHBI-1T |
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T31408-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: DFHBI-1T |
DFHBI 1T |
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D299850 | Toronto Research Chemicals | 100mg | EUR 1200 |
Description: 1539318-36-9 |
Rabbit Anti Human CDK1 Monoclonal Clone DFH-3 |
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IRBAHUCDK1DFH3C100UL | Innovative research | each | EUR 496 |
Description: Rabbit Anti Human CDK1 Monoclonal Clone DFH-3 |
DFHO |
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HY-136277 | MedChemExpress | 1 mg | EUR 238.1 |
Description: DFHO is a fluorogenic ligand of Corn fluorogenic aptamer. The RNA aptamer, Corn binds DFHO with a Kd value of 70 nM and converts it to a fluorescent form, enabling RNA imaging in cells[1][2]. |
DFHO |
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MBS5781026-10mg | MyBiosource | 10(mg | EUR 435 |
DFHO |
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MBS5781026-5mg | MyBiosource | 5mg | EUR 915 |
DFHO |
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MBS5781026-5x10mg | MyBiosource | 5x10mg | EUR 1795 |
DFHO |
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MBS5781026-5x5mg | MyBiosource | 5x5mg | EUR 3970 |
DFHO |
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T31409-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: DFHO |
DFHO |
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T31409-1g | TargetMol Chemicals | 1g | Ask for price |
Description: DFHO |
DFHO |
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T31409-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: DFHO |
DFHO |
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T31409-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: DFHO |
DFHO |
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T31409-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: DFHO |
DF/DFH Column WITH Collection Tube |
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DFB50 | Geneaid Biotech | each | EUR 10.6 |
DF/DFH Column WITH Collection Tube |
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DFB5K | Geneaid Biotech | each | EUR 937 |
DF/DFH Column WITHOUT Collection Tube |
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DFT50 | Geneaid Biotech | each | EUR 9.7 |
DF/DFH Column WITHOUT Collection Tube |
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DFT5K | Geneaid Biotech | each | EUR 840 |