Background and Purpose- The function of irritation in ischemic white matter illness is more and more acknowledged, and additional understanding of the pathophysiology may inform future remedy methods. Multiple sclerosis (MS) is a continual autoimmune situation wherein irritation performs a central function that additionally impacts the white matter.
We hypothesized that white matter damage may share widespread mechanisms and used statistical genetics methods to evaluate whether or not having genetically elevated white matter hyperintensity (WMH) quantity was related to elevated MS threat. Methods- We investigated the genetic affiliation in 2 cohorts with magnetic resonance imaging-quantified ischemic white matter lesion quantity (WMH in stroke; n=2797 and UK Biobank; n=8353) and 14 802 circumstances of MS and 26 703 controls from the International Multiple Sclerosis Genetics Consortium.
We additional carried out individual-level polygenic threat rating calculations for MS and measures of structural white matter illness in UK Biobank. Finally, we seemed for proof of overlapping threat throughout the entire genome. Results- There was no affiliation of genetic variants influencing MS with WMH quantity utilizing abstract statistics within the WMH in stroke cohort (relative threat rating =1.014; 95% CI, 0.936-1.110) or within the UK Biobank cohort (relative threat rating =1.030; 95% CI, 0.932-1.117). Conversely, assessing the contribution of single nucleotide polymorphisms considerably related to WMH on the danger of MS there was no important affiliation (relative threat rating =0.930; 95% CI, 0.736-1.191).

There have been no important associations between polygenic threat scores calculations; these outcomes have been strong to the choice of single nucleotide polymorphisms at a spread of significance thresholds. Whole genome evaluation didn’t reveal any overlap of threat between the traits. Conclusions- Our outcomes don’t present proof to counsel a shared mechanism of white matter harm in ischemia and MS. We suggest that irritation acts in distinct pathways as a result of of the differing nature of the first insult.
Talc powder |
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GK0095-1KG | Glentham Life Sciences | 1 kg | EUR 60 |
Talc powder |
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GK0095-2500G | Glentham Life Sciences | 2500 g | EUR 78 |
Talc powder |
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GK0095-500G | Glentham Life Sciences | 500 g | EUR 50.4 |
PVPP Powder |
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PVPP-10 | BioAssay Systems | 10 | EUR 15 |
Description: Polyvinylpyrrolidone (PVPP) used for preparation of wine samples for use with the Histamine Quick Test Strips. |
Lead Powder |
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GX1060-1 | Glentham Life Sciences | 1 | EUR 189 |
Talc powder |
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GK0095-1 | Glentham Life Sciences | 1 | EUR 19.8 |
Talc powder |
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GK0095-100 | Glentham Life Sciences | 100 | EUR 9.8 |
Talc powder |
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GK0095-2500 | Glentham Life Sciences | 2500 | EUR 34.8 |
Talc powder |
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GK0095-500 | Glentham Life Sciences | 500 | EUR 13 |
IMDM, powder |
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PM150510P-110L | Elabscience Biotech | 1×10 L | EUR 45 |
Description: Classical Basic Medium |
IMDM, powder |
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PM150510P-150L | Elabscience Biotech | 1×50 L | EUR 208 |
Description: Classical Basic Medium |
IMDM, powder |
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PM150510P-51L | Elabscience Biotech | 5×1 L | EUR 35 |
Description: Classical Basic Medium |
M199, powder |
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PM150610P-110L | Elabscience Biotech | 1×10 L | EUR 45 |
Description: Classical Basic Medium |
M199, powder |
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PM150610P-150L | Elabscience Biotech | 1×50 L | EUR 158 |
Description: Classical Basic Medium |
M199, powder |
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PM150610P-51L | Elabscience Biotech | 5×1 L | EUR 35 |
Description: Classical Basic Medium |
Agar, powder |
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01028-14 | NACALAI TESQUE | 10KG | EUR 935.9 |
Agar, powder |
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01028-85 | NACALAI TESQUE | 500G | EUR 70 |
Carbon Powder |
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CARB-10 | BioAssay Systems | 10 | EUR 17 |
Description: Carbon powder used for preparation of urine samples for use with the Oxalate Quick Test Strips. Quantity: 10 tubes of 50 mg carbon powder. |
Tryptone Powder |
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TG217(G211) | Bio Basic | 100g | EUR 73.34 |
Puromycin,Powder |
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CR028-001 | GenDepot | 100mg | EUR 230.4 |
Puromycin,Powder |
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CR028-005 | GenDepot | 500mg | EUR 619.2 |
Puromycin,Powder |
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CR028-101 | GenDepot | 1g | EUR 1081.2 |
Azaperone (powder) |
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50R-R1929 | Fitzgerald | 50 mg | EUR 159.6 |
Description: Azaperone chemical reference substance |
Closantel (powder) |
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50R-R23050 | Fitzgerald | 50 mg | EUR 216 |
Description: Closantel chemical reference substance |
Cisapride (powder) |
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50R-R51619 | Fitzgerald | 50 mg | EUR 159.6 |
Description: Cisapride chemical reference substance |
Albuterol (powder) |
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51R-U012600 | Fitzgerald | 200 mg | EUR 619.2 |
Description: Albuterol chemical reference substance |
Aluminium, powder |
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GX6811-1KG | Glentham Life Sciences | 1 kg | EUR 103.2 |
Aluminium, powder |
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GX6811-250G | Glentham Life Sciences | 250 g | EUR 60 |
Aluminium, powder |
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GX6811-500G | Glentham Life Sciences | 500 g | EUR 74.4 |
Aluminium, powder |
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GX6811-1 | Glentham Life Sciences | 1 | EUR 82.9 |
Aluminium, powder |
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GX6811-250 | Glentham Life Sciences | 250 | EUR 27.1 |
Aluminium, powder |
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GX6811-500 | Glentham Life Sciences | 500 | EUR 47.4 |
RPMI 1640 Powder |
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90-022PB | Scientific Laboratory Supplies | EACH | EUR 57.6 |
Diclazuril (powder) |
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50R-R62370 | Fitzgerald | 50 mg | EUR 289.2 |
Description: Diclazuril chemical reference substance |
Diclazuril (powder) |
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50R-R62646 | Fitzgerald | 50 mg | EUR 289.2 |
Description: Diclazuril chemical reference substance |
Diclazuril (powder) |
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97R-1003 | Fitzgerald | 100 mg | EUR 224.4 |
Description: Diclazuril chemical reference substance |
HEMOGLOBIN POWDER |
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H08-103-10kg | Alphabiosciences | 10 kg | EUR 2444.4 |
HEMOGLOBIN POWDER |
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H08-103-2Kg | Alphabiosciences | 2 Kg | EUR 536.4 |
HEMOGLOBIN POWDER |
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H08-103-500g | Alphabiosciences | 500 g | EUR 178.8 |
Bromperidol (powder) |
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50R-R11333 | Fitzgerald | 50 mg | EUR 159.6 |
Description: Bromperidol chemical reference substance |
Flunarizine (powder) |
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50R-R18545 | Fitzgerald | 50 mg | EUR 159.6 |
Description: Flunarizine chemical reference substance |
Risperidone powder |
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97R-1001 | Fitzgerald | 10 mg | EUR 289.2 |
Description: Purified Risperidone powder |
Flubendazole (powder) |
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50R-R17890 | Fitzgerald | 50 mg | EUR 216 |
Description: Flubendazole chemical reference substance |
Enilconazole (powder) |
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50R-R30617 | Fitzgerald | 50 mg | EUR 216 |
Description: Enilconazole chemical reference substance |
Ketoconazole (powder) |
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50R-R41400 | Fitzgerald | 50 mg | EUR 159.6 |
Description: Ketoconazole chemical reference substance |
Iron Powder, 99.99+% |
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GX1889-10 | Glentham Life Sciences | 10 | EUR 203.6 |
DMEM/F12, powder |
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PM150312P-110L | Elabscience Biotech | 1×10 L | EUR 45 |
Description: Classical Basic Medium |
DMEM/F12, powder |
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PM150312P-150L | Elabscience Biotech | 1×50 L | EUR 158 |
Description: Classical Basic Medium |
DMEM/F12, powder |
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PM150312P-51L | Elabscience Biotech | 5×1 L | EUR 35 |
Description: Classical Basic Medium |
McCoy's 5A, powder |
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PM150710P-110L | Elabscience Biotech | 1×10 L | EUR 45 |
Description: Classical Basic Medium |
McCoy's 5A, powder |
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PM150710P-150L | Elabscience Biotech | 1×50 L | EUR 158 |
Description: Classical Basic Medium |
McCoy's 5A, powder |
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PM150710P-51L | Elabscience Biotech | 5×1 L | EUR 35 |
Description: Classical Basic Medium |
Congo Red Powder |
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abx090680-5g | Abbexa | 5 g | EUR 226.8 |
Erbium Powder, 99.9% |
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GX6516-25 | Glentham Life Sciences | 25 | EUR 439.9 |
Erbium Powder, 99.9% |
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GX6516-5 | Glentham Life Sciences | 5 | EUR 143.2 |
SKIM MILK POWDER |
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S19-121-10kg | Alphabiosciences | 10 kg | Ask for price |
SKIM MILK POWDER |
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S19-121-2Kg | Alphabiosciences | 2 Kg | Ask for price |
SKIM MILK POWDER |
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S19-121-500g | Alphabiosciences | 500 g | Ask for price |
100g HEPES Powder |
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61-034-RM | Scientific Laboratory Supplies | EACH | EUR 119.7 |
500g HEPES Powder |
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61-034-RO | Scientific Laboratory Supplies | EACH | EUR 228 |
1000g HEPES Powder |
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61-034-RR | Scientific Laboratory Supplies | EACH | EUR 563.16 |
Holmium Powder, 99.9% |
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GX8288-25 | Glentham Life Sciences | 25 | EUR 602.9 |
Holmium Powder, 99.9% |
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GX8288-5 | Glentham Life Sciences | 5 | EUR 207 |
Terbium Powder, 99.9% |
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GX9185-1 | Glentham Life Sciences | 1 | EUR 132.6 |
Terbium Powder, 99.9% |
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GX9185-5 | Glentham Life Sciences | 5 | EUR 392.6 |
Gellan Gum Powder |
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30630090-1 | Bio-WORLD | - | EUR 60.19 |
Description: Gellan Gum |
Gellan Gum Powder |
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30630090-2 | Bio-WORLD | - | EUR 100.91 |
Description: Gellan Gum |
Gellan Gum Powder |
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30630090-3 | Bio-WORLD | - | EUR 192.44 |
Description: Gellan Gum |
Lutetium Powder, 99.9% |
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GX3553-2 | Glentham Life Sciences | 2 | EUR 754.4 |
Samarium Powder, 99.9% |
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GX0211-10 | Glentham Life Sciences | 10 | EUR 198.7 |
Samarium Powder, 99.9% |
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GX0211-50 | Glentham Life Sciences | 50 | EUR 500.3 |
RPMI-1640, powder |
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PM150110P-110L | Elabscience Biotech | 1×10 L | EUR 35 |
Description: Classical Basic Medium |
RPMI-1640, powder |
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PM150110P-150L | Elabscience Biotech | 1×50 L | EUR 128 |
Description: Classical Basic Medium |
RPMI-1640, powder |
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PM150110P-51L | Elabscience Biotech | 5×1 L | EUR 30 |
Description: Classical Basic Medium |
Beef Extract Powder |
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CH016 | ABM | 50 g | EUR 152.4 |
Beef Extract Powder |
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CH017 | ABM | 100 g | EUR 170.4 |
Beef Extract Powder |
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CH018 | ABM | 500 g | EUR 289.2 |
Giemsa stain, powder |
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GT7801-100G | Glentham Life Sciences | 100 g | EUR 160.8 |
Giemsa stain, powder |
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GT7801-10G | Glentham Life Sciences | 10 g | EUR 55.2 |
Giemsa stain, powder |
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GT7801-25G | Glentham Life Sciences | 25 g | EUR 74.4 |
Giemsa stain, powder |
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GT7801-50G | Glentham Life Sciences | 50 g | EUR 103.2 |
Giemsa stain, powder |
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GT7801-5G | Glentham Life Sciences | 5 g | EUR 50.4 |
Giemsa stain, powder |
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GT7801-10 | Glentham Life Sciences | 10 | EUR 15.9 |
Giemsa stain, powder |
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GT7801-100 | Glentham Life Sciences | 100 | EUR 102.7 |
Giemsa stain, powder |
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GT7801-25 | Glentham Life Sciences | 25 | EUR 31.7 |
Giemsa stain, powder |
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GT7801-5 | Glentham Life Sciences | 5 | EUR 13 |
Giemsa stain, powder |
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GT7801-50 | Glentham Life Sciences | 50 | EUR 55.4 |
Ytterbium Powder, 99.9% |
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GX5748-25 | Glentham Life Sciences | 25 | EUR 860.3 |
Ytterbium Powder, 99.9% |
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GX5748-5 | Glentham Life Sciences | 5 | EUR 280.2 |
Lanthanum Powder, 99.9% |
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GX6829-10 | Glentham Life Sciences | 10 | EUR 342.3 |
Lanthanum Powder, 99.9% |
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GX6829-50 | Glentham Life Sciences | 50 | EUR 1198.1 |
Tungsten Powder M10 |
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40000052-1 | Bio-WORLD | 25 g | EUR 334.19 |
Tin Powder -100 mesh, 99.995% |
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GX2142-10 | Glentham Life Sciences | 10 | EUR 177.5 |
Tin Powder -100 mesh, 99.995% |
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GX2142-100 | Glentham Life Sciences | 100 | EUR 863.6 |
Tin Powder -100 mesh, 99.995% |
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GX2142-25 | Glentham Life Sciences | 25 | EUR 325.9 |
Soya lecithin, powder |
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GE0442-100G | Glentham Life Sciences | 100 g | EUR 55.2 |
Soya lecithin, powder |
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GE0442-1KG | Glentham Life Sciences | 1 kg | EUR 132 |
Soya lecithin, powder |
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GE0442-250G | Glentham Life Sciences | 250 g | EUR 69.6 |
Soya lecithin, powder |
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GE0442-500G | Glentham Life Sciences | 500 g | EUR 93.6 |
Yeast extract, powder |
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GE4420-100G | Glentham Life Sciences | 100 g | EUR 51.6 |
Yeast extract, powder |
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GE4420-1KG | Glentham Life Sciences | 1 kg | EUR 132 |
Yeast extract, powder |
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GE4420-250G | Glentham Life Sciences | 250 g | EUR 64.8 |
Yeast extract, powder |
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GE4420-500G | Glentham Life Sciences | 500 g | EUR 93.6 |
Gadolinium Powder, 99.9% |
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GX8077-25 | Glentham Life Sciences | 25 | EUR 396 |
Gadolinium Powder, 99.9% |
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GX8077-5 | Glentham Life Sciences | 5 | EUR 132.6 |
Dysprosium Powder, 99.9% |
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GX8361-25 | Glentham Life Sciences | 25 | EUR 386.2 |
Dysprosium Powder, 99.9% |
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GX8361-5 | Glentham Life Sciences | 5 | EUR 134.1 |
Soya lecithin, powder |
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GE0442-1 | Glentham Life Sciences | 1 | EUR 79.1 |
Soya lecithin, powder |
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GE0442-100 | Glentham Life Sciences | 100 | EUR 15.9 |
Soya lecithin, powder |
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GE0442-250 | Glentham Life Sciences | 250 | EUR 27.8 |
Soya lecithin, powder |
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GE0442-500 | Glentham Life Sciences | 500 | EUR 47.4 |
Yeast extract, powder |
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GE4420-1 | Glentham Life Sciences | 1 | EUR 105.5 |
Yeast extract, powder |
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GE4420-100 | Glentham Life Sciences | 100 | EUR 18.3 |
Yeast extract, powder |
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GE4420-250 | Glentham Life Sciences | 250 | EUR 36.9 |
Yeast extract, powder |
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GE4420-500 | Glentham Life Sciences | 500 | EUR 63.3 |
Agar Purified, powder |
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01056-15 | NACALAI TESQUE | 500G | EUR 105 |
Agar Purified, powder |
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01162-15 | NACALAI TESQUE | 500G | EUR 117.25 |
Nourseothricin - Powder, 100 g |
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M-AB-102-100G | MiTeGen | 100 g | EUR 19309 |
Description: Nourseothricin - Powder, 100 g |
Citrate Buffer Powder |
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AR0024 | BosterBio | 2000mL/pack | EUR 63.6 |
Nor Astemizole (powder) |
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50R-R53993 | Fitzgerald | 50 mg | EUR 289.2 |
Description: Nor Astemizole chemical reference substance |
Magnesium, powder, 150 - 350 mesh |
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GX0342-100G | Glentham Life Sciences | 100 g | EUR 69.6 |
Magnesium, powder, 150 - 350 mesh |
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GX0342-100 | Glentham Life Sciences | 100 | EUR 27.6 |
SILAC- RPMI 1640, powder |
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432 | AthenaES | 1L | EUR 105.6 |
1g X-GAL Powder |
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46-101-RF | Scientific Laboratory Supplies | EACH | EUR 312.36 |
Ham's F-12, powder |
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PM150810P-110L | Elabscience Biotech | 1×10 L | EUR 45 |
Description: Classical Basic Medium |
Ham's F-12, powder |
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PM150810P-150L | Elabscience Biotech | 1×50 L | EUR 158 |
Description: Classical Basic Medium |
Ham's F-12, powder |
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PM150810P-51L | Elabscience Biotech | 5×1 L | EUR 35 |
Description: Classical Basic Medium |
Nickel Powder - 100 mesh, 99.99% |
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GX6574-100 | Glentham Life Sciences | 100 | EUR 182.5 |
Nickel Powder - 100 mesh, 99.99% |
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GX6574-25 | Glentham Life Sciences | 25 | EUR 105.5 |