Background and Purpose- The function of irritation in ischemic white matter illness is more and more acknowledged, and additional understanding of the pathophysiology may inform future remedy methods. Multiple sclerosis (MS) is a continual autoimmune situation wherein irritation performs a central function that additionally impacts the white matter.
We hypothesized that white matter damage may share widespread mechanisms and used statistical genetics methods to evaluate whether or not having genetically elevated white matter hyperintensity (WMH) quantity was related to elevated MS threat. Methods- We investigated the genetic affiliation in 2 cohorts with magnetic resonance imaging-quantified ischemic white matter lesion quantity (WMH in stroke; n=2797 and UK Biobank; n=8353) and 14 802 circumstances of MS and 26 703 controls from the International Multiple Sclerosis Genetics Consortium.
We additional carried out individual-level polygenic threat rating calculations for MS and measures of structural white matter illness in UK Biobank. Finally, we seemed for proof of overlapping threat throughout the entire genome. Results- There was no affiliation of genetic variants influencing MS with WMH quantity utilizing abstract statistics within the WMH in stroke cohort (relative threat rating =1.014; 95% CI, 0.936-1.110) or within the UK Biobank cohort (relative threat rating =1.030; 95% CI, 0.932-1.117). Conversely, assessing the contribution of single nucleotide polymorphisms considerably related to WMH on the danger of MS there was no important affiliation (relative threat rating =0.930; 95% CI, 0.736-1.191).
There have been no important associations between polygenic threat scores calculations; these outcomes have been strong to the choice of single nucleotide polymorphisms at a spread of significance thresholds. Whole genome evaluation didn’t reveal any overlap of threat between the traits. Conclusions- Our outcomes don’t present proof to counsel a shared mechanism of white matter harm in ischemia and MS. We suggest that irritation acts in distinct pathways as a result of of the differing nature of the first insult.
Defined Nutrient Powder (DNP) #1 (Powder) |
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| MBS653137-25L | MyBiosource | 25L | EUR 710 |
Defined Nutrient Powder (DNP) #1 (Powder) |
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| MBS653137-5x25L | MyBiosource | 5x25L | EUR 2800 |
Defined Nutrient Powder Modified SAAMB (Powder) |
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| MBS653008-100g | MyBiosource | 100g | EUR 285 |
Defined Nutrient Powder Modified SAAMB (Powder) |
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| MBS653008-1kg | MyBiosource | 1kg | EUR 1070 |
Defined Nutrient Powder Modified SAAMB (Powder) |
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| MBS653008-500g | MyBiosource | 500g | EUR 780 |
Defined Nutrient Powder Modified SAAMB (Powder) |
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| MBS653008-5x1kg | MyBiosource | 5x1kg | EUR 4715 |
Tin, powder |
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| 33927-02 | NACALAI TESQUE | 25G | EUR 14 |
Tin, powder |
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| 33927-15 | NACALAI TESQUE | 500G | EUR 65.1 |
TBS(powder) |
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| EZWB22-S-2L | Shanghai WSHT Biotechnology | 2L | EUR 1.2 |
PBS(powder) |
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| EZWB23-S-2L | Shanghai WSHT Biotechnology | 2L | EUR 1.2 |
Tin Powder |
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| T444145 | Toronto Research Chemicals | 25g | EUR 58 |
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Description: 7440-31-5 |
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GMS POWDER |
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| G07-103-10kg | Alphabiosciences | 10 kg | EUR 60 |
GMS POWDER |
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| G07-103-2Kg | Alphabiosciences | 2 Kg | EUR 60 |
GMS POWDER |
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| G07-103-500g | Alphabiosciences | 500 g | EUR 60 |
Dextran Powder 6000MW |
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| MBS651718-1kg | MyBiosource | 1kg | EUR 475 |
Dextran Powder 6000MW |
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| MBS651718-25kg | MyBiosource | 2.5kg | EUR 1070 |
Dextran Powder 6000MW |
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| MBS651718-500g | MyBiosource | 500g | EUR 335 |
Dextran Powder 6000MW |
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| MBS651718-5x25kg | MyBiosource | 5x2.5kg | EUR 4535 |
Dextran Powder 100,000MW |
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| MBS651727-100g | MyBiosource | 100g | EUR 715 |
Dextran Powder 100,000MW |
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| MBS651727-10g | MyBiosource | 10g | EUR 335 |
Dextran Powder 100,000MW |
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| MBS651727-25g | MyBiosource | 25g | EUR 500 |
Dextran Powder 100,000MW |
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| MBS651727-50g | MyBiosource | 50g | EUR 640 |
Dextran Powder 100,000MW |
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| MBS651727-5x100g | MyBiosource | 5x100g | EUR 3075 |
Dextran Powder 250,000MW |
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| MBS651780-1kg | MyBiosource | 1kg | EUR 475 |
Dextran Powder 250,000MW |
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| MBS651780-25kg | MyBiosource | 2.5kg | EUR 1070 |
Dextran Powder 250,000MW |
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| MBS651780-500g | MyBiosource | 500g | EUR 335 |
Dextran Powder 250,000MW |
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| MBS651780-5x25kg | MyBiosource | 5x2.5kg | EUR 4535 |
Dextran Powder 500,000MW |
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| MBS651799-100g | MyBiosource | 100g | EUR 500 |
Dextran Powder 500,000MW |
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| MBS651799-1kg | MyBiosource | 1kg | EUR 1925 |
Dextran Powder 500,000MW |
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| MBS651799-250g | MyBiosource | 250g | EUR 695 |
Dextran Powder 500,000MW |
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| MBS651799-25g | MyBiosource | 25g | EUR 290 |
Dextran Powder 500,000MW |
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| MBS651799-500g | MyBiosource | 500g | EUR 1040 |
Agar, powder |
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| 01028-14 | NACALAI TESQUE | 10KG | EUR 935.9 |
Agar, powder |
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| 01028-85 | NACALAI TESQUE | 500G | EUR 70 |
Zinc Powder |
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| 36906-95 | NACALAI TESQUE | 500G | EUR 17.5 |
Zinc Powder |
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| 36936-34 | NACALAI TESQUE | 250G | EUR 44.1 |
Iron, powder |
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| 19416-45 | NACALAI TESQUE | 500G | EUR 13.65 |
Iron, powder |
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| 19417-35 | NACALAI TESQUE | 500G | EUR 32.9 |
Iron, powder |
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| 19418-25 | NACALAI TESQUE | 500G | EUR 52.5 |
IMDM (Powder) |
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| abx295013-100g | Abbexa | 100 µg | Ask for price |
IMDM (Powder) |
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| abx295013-20g | Abbexa | 20 µg | EUR 75 |
IMDM (Powder) |
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| abx295013-50g | Abbexa | 50 µg | EUR 212.5 |
M199 (Powder) |
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| abx295014-100g | Abbexa | 100 µg | Ask for price |
M199 (Powder) |
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| abx295014-20g | Abbexa | 20 µg | EUR 62.5 |
M199 (Powder) |
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| abx295014-50g | Abbexa | 50 µg | EUR 162.5 |
Iron powder |
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| I04505 | Pfaltz & Bauer | 100G | EUR 104.72 |
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Description: CAS N° 7439-89-6 |
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Lead Powder |
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| GX1060 | Glentham Life Sciences | 1kg | EUR 196.37 |
Lead Powder |
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| GX1060-1 | Glentham Life Sciences | 1 | EUR 189 |
Talc powder |
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| GK0095 | Glentham Life Sciences | 100g | EUR 31.83 |
Talc powder |
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| GK0095-1 | Glentham Life Sciences | 1 | EUR 19.8 |
Talc powder |
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| GK0095-100 | Glentham Life Sciences | 100 | EUR 9.8 |
Talc powder |
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| GK0095-100G | Glentham Life Sciences | 100 g | EUR 45.6 |
Talc powder |
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| GK0095-1KG | Glentham Life Sciences | 1 kg | EUR 60 |
Talc powder |
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| GK0095-2500 | Glentham Life Sciences | 2500 | EUR 34.8 |
Talc powder |
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| GK0095-2500G | Glentham Life Sciences | 2500 g | EUR 78 |
Talc powder |
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| GK0095-500 | Glentham Life Sciences | 500 | EUR 13 |
Talc powder |
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| GK0095-500G | Glentham Life Sciences | 500 g | EUR 50.4 |
BCYE (Powder) |
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| MBS653364-500g | MyBiosource | 500g | EUR 660 |
BCYE (Powder) |
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| MBS653364-5x500g | MyBiosource | 5x500g | EUR 2825 |
IMDM, powder |
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| PM150510P | Elabscience Biotech | 5×1L | EUR 35 |
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Description: IMDM |
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IMDM, powder |
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| PM150510P-110L | Elabscience Biotech | 1×10 L | EUR 45 |
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Description: Classical Basic Medium |
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IMDM, powder |
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| PM150510P-150L | Elabscience Biotech | 1×50 L | EUR 208 |
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Description: Classical Basic Medium |
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IMDM, powder |
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| PM150510P-51L | Elabscience Biotech | 5×1 L | EUR 35 |
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Description: Classical Basic Medium |
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M199, powder |
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| PM150610P | Elabscience Biotech | 5×1L | EUR 35 |
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Description: M199 |
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M199, powder |
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| PM150610P-110L | Elabscience Biotech | 1×10 L | EUR 45 |
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Description: Classical Basic Medium |
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M199, powder |
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| PM150610P-150L | Elabscience Biotech | 1×50 L | EUR 158 |
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Description: Classical Basic Medium |
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M199, powder |
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| PM150610P-51L | Elabscience Biotech | 5×1 L | EUR 35 |
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Description: Classical Basic Medium |
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Zinc powder |
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| Z00066 | Pfaltz & Bauer | 100G | EUR 95.2 |
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Description: CAS N° 7440-66-6 |
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PVPP Powder |
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| PVPP-10 | BioAssay Systems | 10 | EUR 19 |
Honey Powder |
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| EXTC-123 | Creative Enzymes | 1 kg | EUR 198 |
Skim Milk Powder (SM Powder) BactoBio for bacteriology |
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| 28582 | Sisco Laboratories | 500 Gms | EUR 9.41 |
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Description: Part D |
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Sulfur, powder |
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| 32513-55 | NACALAI TESQUE | 500G | EUR 11.9 |
Silver, powder |
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| 30934-92 | NACALAI TESQUE | 25G | EUR 47.25 |
BANANA POWDER |
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| B852 | PhytoTechnology Laboratories | 100G | EUR 59.11 |
Cobalt powder |
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| C23440 | Pfaltz & Bauer | 100G | EUR 126 |
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Description: CAS N° 7440-48-4 |
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Copper Powder |
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| C685340 | Toronto Research Chemicals | 2.5g | EUR 425 |
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Description: 7440-50-8 |
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Indium (powder) |
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| I533700 | Toronto Research Chemicals | 10g | EUR 150 |
Litmus powder |
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| L04635 | Pfaltz & Bauer | 25G | EUR 217.8 |
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Description: CAS N° 1393-92-6 |
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Indium (powder) |
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| MBS6065057-1g | MyBiosource | 1(g | EUR 500 |
Indium (powder) |
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| MBS6065057-5x1g | MyBiosource | 5x1g | EUR 2090 |
Nickel powder |
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| N04560 | Pfaltz & Bauer | 100G | EUR 100.64 |
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Description: CAS N° 7440-02-0 |
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POTATO POWDER |
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| P692 | PhytoTechnology Laboratories | 100G | EUR 21.4 |
TOMATO POWDER |
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| T872 | PhytoTechnology Laboratories | 1KG | EUR 62.7 |
Copper Powder |
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| TRC-C685340-5G | Toronto Research Chemicals | 5 g | Ask for price |
Copper Powder |
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| TRC-C685340-2.5G | Toronto Research Chemicals | 2.5 g | Ask for price |
Indium (powder) |
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| TRC-I533700-10G | Toronto Research Chemicals | 10 g | Ask for price |
Copper Powder |
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| TRC-C685340-500MG | Toronto Research Chemicals | 500 mg | Ask for price |
Carbon Powder |
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| CARB-10 | BioAssay Systems | 10 | EUR 19 |
Indium (powder) |
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| TRC-I533700-1G | Toronto Research Chemicals | 1 g | Ask for price |
Germanium powder 99.999% |
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| G01170 | Pfaltz & Bauer | 5G | EUR 204.33 |
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Description: CAS N° 7440-56-4 |
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Dextran Powder 20,000MW |
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| MBS651808-1kg | MyBiosource | 1kg | EUR 750 |
Dextran Powder 20,000MW |
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| MBS651808-25kg | MyBiosource | 2.5kg | EUR 1550 |
Dextran Powder 20,000MW |
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| MBS651808-500g | MyBiosource | 500g | EUR 490 |
Dextran Powder 20,000MW |
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| MBS651808-5x25kg | MyBiosource | 5x2.5kg | EUR 6705 |
Silicon, powder |
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| 30928-95 | NACALAI TESQUE | 500G | EUR 115.5 |
Silicon, powder |
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| 30929-72 | NACALAI TESQUE | 25G | EUR 25.2 |
Bismuth powder |
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| B15270 | Pfaltz & Bauer | 50G | EUR 130.64 |
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Description: CAS N° 7440-69-9 |
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COCONUT POWDER |
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| C187 | PhytoTechnology Laboratories | 100G | EUR 59.11 |
Trypsin Powder |
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| T32855 | Pfaltz & Bauer | 1G | EUR 227.06 |
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Description: CAS N° 2594141 |
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Selenium, powder |
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| 30532-52 | NACALAI TESQUE | 25G | EUR 19.6 |
Blocking Powder |
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| E-IR-R108-10g | Elabscience Biotech | 10g | EUR 100 |
Blocking Powder |
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| E-IR-R108-50g | Elabscience Biotech | 50g | EUR 400 |
Blocking Powder |
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| E-IR-R108-5g | Elabscience Biotech | 5g | EUR 60 |
Blocking Powder |
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| E-IR-R108-each | Elabscience Biotech | each | Ask for price |
Cinnamon Powder |
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| EXTC-118 | Creative Enzymes | 1 kg | EUR 198 |
Tryptone Powder |
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| TG217(G211) | Bio Basic | 100g | EUR 73.34 |
Chitosan Powder |
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| 103640 100 | Unisource Chemicals | 100 g | Ask for price |
Chitosan Powder |
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| 103640 25 | Unisource Chemicals | 25 g | Ask for price |
Chitosan Powder |
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| 103640 500 | Unisource Chemicals | 500 g | Ask for price |
Platinum powder |
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| 116290 1 | Unisource Chemicals | 1 g | Ask for price |
Platinum powder |
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| 116290 500 | Unisource Chemicals | 500 mg | Ask for price |
Heart Infusion Powder (HI Powder) BactoBio for bacteriology |
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| 28551 | Sisco Laboratories | 500 Gms | EUR 19.67 |
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Description: Part D |
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Heart Infusion Powder (HI Powder) BactoBio for bacteriology |
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| 28551-1 | Sisco Laboratories | 2.5 Kg | EUR 88.09 |
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Description: Part D |
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Potato Infusion Powder (PI Powder) BactoBio for bacteriology |
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| 60040 | Sisco Laboratories | 100 Gms | EUR 6.84 |
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Description: Part D |
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Potato Infusion Powder (PI Powder) BactoBio for bacteriology |
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| 60040-1 | Sisco Laboratories | 500 Gms | EUR 21.38 |
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Description: Part D |
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Tellurium, powder |
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| 32716-92 | NACALAI TESQUE | 25G | EUR 40.25 |
Puromycin,Powder |
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| CR028-001 | GenDepot | 100mg | EUR 115 |
Puromycin,Powder |
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| CR028-005 | GenDepot | 500mg | EUR 370 |
Puromycin,Powder |
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| CR028-101 | GenDepot | 1g | EUR 660 |
Aluminium, powder |
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| GX6811 | Glentham Life Sciences | 250g | EUR 75.95 |
Aluminium, powder |
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| GX6811-1 | Glentham Life Sciences | 1 | EUR 82.9 |
Aluminium, powder |
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| GX6811-1KG | Glentham Life Sciences | 1 kg | EUR 103.2 |
Aluminium, powder |
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| GX6811-250 | Glentham Life Sciences | 250 | EUR 27.1 |
Aluminium, powder |
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| GX6811-250G | Glentham Life Sciences | 250 g | EUR 60 |
Aluminium, powder |
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| GX6811-500 | Glentham Life Sciences | 500 | EUR 47.4 |
Aluminium, powder |
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| GX6811-500G | Glentham Life Sciences | 500 g | EUR 74.4 |
Azaperone (powder) |
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| MBS539887-50mg | MyBiosource | 50mg | EUR 195 |
Azaperone (powder) |
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| MBS539887-5x50mg | MyBiosource | 5x50mg | EUR 735 |
Closantel (powder) |
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| MBS539889-50mg | MyBiosource | 50mg | EUR 320 |