Background and Purpose- The function of irritation in ischemic white matter illness is more and more acknowledged, and additional understanding of the pathophysiology may inform future remedy methods. Multiple sclerosis (MS) is a continual autoimmune situation wherein irritation performs a central function that additionally impacts the white matter.
We hypothesized that white matter damage may share widespread mechanisms and used statistical genetics methods to evaluate whether or not having genetically elevated white matter hyperintensity (WMH) quantity was related to elevated MS threat. Methods- We investigated the genetic affiliation in 2 cohorts with magnetic resonance imaging-quantified ischemic white matter lesion quantity (WMH in stroke; n=2797 and UK Biobank; n=8353) and 14 802 circumstances of MS and 26 703 controls from the International Multiple Sclerosis Genetics Consortium.
We additional carried out individual-level polygenic threat rating calculations for MS and measures of structural white matter illness in UK Biobank. Finally, we seemed for proof of overlapping threat throughout the entire genome. Results- There was no affiliation of genetic variants influencing MS with WMH quantity utilizing abstract statistics within the WMH in stroke cohort (relative threat rating =1.014; 95% CI, 0.936-1.110) or within the UK Biobank cohort (relative threat rating =1.030; 95% CI, 0.932-1.117). Conversely, assessing the contribution of single nucleotide polymorphisms considerably related to WMH on the danger of MS there was no important affiliation (relative threat rating =0.930; 95% CI, 0.736-1.191).
There have been no important associations between polygenic threat scores calculations; these outcomes have been strong to the choice of single nucleotide polymorphisms at a spread of significance thresholds. Whole genome evaluation didn’t reveal any overlap of threat between the traits. Conclusions- Our outcomes don’t present proof to counsel a shared mechanism of white matter harm in ischemia and MS. We suggest that irritation acts in distinct pathways as a result of of the differing nature of the first insult.
Talc powder |
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| GK0095-1KG | Glentham Life Sciences | 1 kg | EUR 60 |
Talc powder |
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| GK0095-2500G | Glentham Life Sciences | 2500 g | EUR 78 |
Talc powder |
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| GK0095-500G | Glentham Life Sciences | 500 g | EUR 50.4 |
PVPP Powder |
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| PVPP-10 | BioAssay Systems | 10 | EUR 15 |
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Description: Polyvinylpyrrolidone (PVPP) used for preparation of wine samples for use with the Histamine Quick Test Strips. |
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Carbon Powder |
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| CARB-10 | BioAssay Systems | 10 | EUR 17 |
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Description: Carbon powder used for preparation of urine samples for use with the Oxalate Quick Test Strips. Quantity: 10 tubes of 50 mg carbon powder. |
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Zeocin, powder |
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| GX3094-100MG | Glentham Life Sciences | 100 mg | EUR 202.8 |
Tryptone Powder |
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| TG217(G211) | Bio Basic | 100g | EUR 73.34 |
Azaperone (powder) |
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| 50R-R1929 | Fitzgerald | 50 mg | EUR 159.6 |
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Description: Azaperone chemical reference substance |
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Closantel (powder) |
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| 50R-R23050 | Fitzgerald | 50 mg | EUR 216 |
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Description: Closantel chemical reference substance |
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Cisapride (powder) |
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| 50R-R51619 | Fitzgerald | 50 mg | EUR 159.6 |
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Description: Cisapride chemical reference substance |
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Albuterol (powder) |
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| 51R-U012600 | Fitzgerald | 200 mg | EUR 619.2 |
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Description: Albuterol chemical reference substance |
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Puromycin,Powder |
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| CR028-001 | GenDepot | 100mg | EUR 230.4 |
Puromycin,Powder |
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| CR028-005 | GenDepot | 500mg | EUR 619.2 |
Puromycin,Powder |
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| CR028-101 | GenDepot | 1g | EUR 1081.2 |
Aluminium, powder |
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| GX6811-1KG | Glentham Life Sciences | 1 kg | EUR 103.2 |
Aluminium, powder |
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| GX6811-250G | Glentham Life Sciences | 250 g | EUR 60 |
Aluminium, powder |
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| GX6811-500G | Glentham Life Sciences | 500 g | EUR 74.4 |
Diclazuril (powder) |
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| 50R-R62370 | Fitzgerald | 50 mg | EUR 289.2 |
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Description: Diclazuril chemical reference substance |
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Diclazuril (powder) |
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| 50R-R62646 | Fitzgerald | 50 mg | EUR 289.2 |
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Description: Diclazuril chemical reference substance |
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Diclazuril (powder) |
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| 97R-1003 | Fitzgerald | 100 mg | EUR 224.4 |
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Description: Diclazuril chemical reference substance |
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HEMOGLOBIN POWDER |
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| H08-103-10kg | Alphabiosciences | 10 kg | EUR 2444.4 |
HEMOGLOBIN POWDER |
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| H08-103-2Kg | Alphabiosciences | 2 Kg | EUR 536.4 |
HEMOGLOBIN POWDER |
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| H08-103-500g | Alphabiosciences | 500 g | EUR 178.8 |
Bromperidol (powder) |
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| 50R-R11333 | Fitzgerald | 50 mg | EUR 159.6 |
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Description: Bromperidol chemical reference substance |
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Flunarizine (powder) |
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| 50R-R18545 | Fitzgerald | 50 mg | EUR 159.6 |
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Description: Flunarizine chemical reference substance |
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Risperidone powder |
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| 97R-1001 | Fitzgerald | 10 mg | EUR 289.2 |
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Description: Purified Risperidone powder |
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Flubendazole (powder) |
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| 50R-R17890 | Fitzgerald | 50 mg | EUR 216 |
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Description: Flubendazole chemical reference substance |
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Enilconazole (powder) |
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| 50R-R30617 | Fitzgerald | 50 mg | EUR 216 |
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Description: Enilconazole chemical reference substance |
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Ketoconazole (powder) |
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| 50R-R41400 | Fitzgerald | 50 mg | EUR 159.6 |
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Description: Ketoconazole chemical reference substance |
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RPMI 1640 Powder |
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| 90-022PB | Scientific Laboratory Supplies | EACH | EUR 57.6 |
Congo Red Powder |
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| abx090680-5g | Abbexa | 5 g | EUR 226.8 |
SKIM MILK POWDER |
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| S19-121-10kg | Alphabiosciences | 10 kg | Ask for price |
SKIM MILK POWDER |
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| S19-121-2Kg | Alphabiosciences | 2 Kg | Ask for price |
SKIM MILK POWDER |
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| S19-121-500g | Alphabiosciences | 500 g | Ask for price |
100g HEPES Powder |
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| 61-034-RM | Scientific Laboratory Supplies | EACH | EUR 119.7 |
500g HEPES Powder |
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| 61-034-RO | Scientific Laboratory Supplies | EACH | EUR 228 |
1000g HEPES Powder |
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| 61-034-RR | Scientific Laboratory Supplies | EACH | EUR 563.16 |
Beef Extract Powder |
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| CH016 | ABM | 50 g | EUR 152.4 |
Beef Extract Powder |
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| CH017 | ABM | 100 g | EUR 170.4 |
Beef Extract Powder |
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| CH018 | ABM | 500 g | EUR 289.2 |
Giemsa stain, powder |
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| GT7801-100G | Glentham Life Sciences | 100 g | EUR 160.8 |
Giemsa stain, powder |
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| GT7801-10G | Glentham Life Sciences | 10 g | EUR 55.2 |
Giemsa stain, powder |
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| GT7801-25G | Glentham Life Sciences | 25 g | EUR 74.4 |
Giemsa stain, powder |
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| GT7801-50G | Glentham Life Sciences | 50 g | EUR 103.2 |
Giemsa stain, powder |
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| GT7801-5G | Glentham Life Sciences | 5 g | EUR 50.4 |
Soya lecithin, powder |
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| GE0442-100G | Glentham Life Sciences | 100 g | EUR 55.2 |
Soya lecithin, powder |
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| GE0442-1KG | Glentham Life Sciences | 1 kg | EUR 132 |
Soya lecithin, powder |
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| GE0442-250G | Glentham Life Sciences | 250 g | EUR 69.6 |
Soya lecithin, powder |
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| GE0442-500G | Glentham Life Sciences | 500 g | EUR 93.6 |
Yeast extract, powder |
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| GE4420-100G | Glentham Life Sciences | 100 g | EUR 51.6 |
Yeast extract, powder |
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| GE4420-1KG | Glentham Life Sciences | 1 kg | EUR 132 |
Yeast extract, powder |
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| GE4420-250G | Glentham Life Sciences | 250 g | EUR 64.8 |
Yeast extract, powder |
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| GE4420-500G | Glentham Life Sciences | 500 g | EUR 93.6 |
Nor Astemizole (powder) |
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| 50R-R53993 | Fitzgerald | 50 mg | EUR 289.2 |
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Description: Nor Astemizole chemical reference substance |
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Citrate Buffer Powder |
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| AR0024 | BosterBio | 2000mL/pack | EUR 63.6 |
Clocinizine HCL (powder) |
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| 50R-R522 | Fitzgerald | 50 mg | EUR 159.6 |
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Description: Clocinizine HCL chemical reference substance |
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Levamisole OMPI (powder) |
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| 50R-R9280 | Fitzgerald | 50 mg | EUR 159.6 |
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Description: Levamisole OMPI chemical reference substance |
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Nourseothricin - Powder, 100 g |
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| M-AB-102-100G | MiTeGen | 100 g | EUR 19309 |
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Description: Nourseothricin - Powder, 100 g |
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Colistin Sulfate (powder) |
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| 51R-U148001 | Fitzgerald | 200 mg | EUR 619.2 |
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Description: Colistin Sulfate chemical reference substance |
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SILAC- RPMI 1640, powder |
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| 432 | AthenaES | 1L | EUR 105.6 |
1g X-GAL Powder |
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| 46-101-RF | Scientific Laboratory Supplies | EACH | EUR 312.36 |
Econazole Nitrate (powder) |
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| 50R-R14827 | Fitzgerald | 50 mg | EUR 159.6 |
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Description: Econazole Nitrate chemical reference substance |
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Levocabastine HCL (powder) |
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| 50R-R50547 | Fitzgerald | 50 mg | EUR 159.6 |
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Description: Levocabastine HCL chemical reference substance |
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Hemoglobin Powder (bovine) |
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| 97R-1004S | Fitzgerald | 1 Kg | EUR 1318.8 |
Magnesium, powder, 150 - 350 mesh |
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| GX0342-100G | Glentham Life Sciences | 100 g | EUR 69.6 |
25g Chloramphenicol Powder |
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| 61-239-RI | Scientific Laboratory Supplies | EACH | EUR 98.04 |
Powder Funnel 19/26 |
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| QCF5/2 | Scientific Laboratory Supplies | EACH | EUR 56.4 |
Powder Funnel 24/29 |
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| QCF5/3 | Scientific Laboratory Supplies | EACH | EUR 57.6 |
Powder Funnel 29/32 |
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| QCF5/4 | Scientific Laboratory Supplies | EACH | EUR 56.4 |
Medium 199 (Mod) Powder |
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| 90-050PB | Scientific Laboratory Supplies | EACH | EUR 93.48 |
Powder Thief Tip 2ml |
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| SAM1249 | Scientific Laboratory Supplies | EACH | EUR 58.8 |
Powder Thief Tip 3ml |
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| SAM1250 | Scientific Laboratory Supplies | EACH | EUR 58.8 |
Powder Thief Tip 5ml |
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| SAM1251 | Scientific Laboratory Supplies | EACH | EUR 58.8 |
Powder Thief Tip 8ml |
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| SAM1252 | Scientific Laboratory Supplies | EACH | EUR 58.8 |
Powder Thief Tip 10ml |
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| SAM1253 | Scientific Laboratory Supplies | EACH | EUR 58.8 |
Powder Thief Tip 10ml |
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| SAM1257 | Scientific Laboratory Supplies | EACH | EUR 74.4 |
Powder Thief Tip 20ml |
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| SAM1258 | Scientific Laboratory Supplies | EACH | EUR 74.4 |
Powder Thief Tip 25ml |
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| SAM1259 | Scientific Laboratory Supplies | EACH | EUR 74.4 |
Hydroxy-itraconazole (powder) |
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| 50R-R63373 | Fitzgerald | 50 mg | EUR 289.2 |
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Description: Hydroxy-itraconazole chemical reference substance |
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Acetylcholine Chloride (powder) |
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| 51R-U008501 | Fitzgerald | 200 mg | EUR 619.2 |
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Description: Acetylcholine Chloride chemical reference substance |
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Difco Skim Milk Powder 500gm |
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| 232100 | Scientific Laboratory Supplies | EACH | EUR 55.2 |
1g G418 Sulfate Powder |
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| 61-234-RF | Scientific Laboratory Supplies | EACH | EUR 135.66 |
Ox bile extract powder |
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| OBE-001 | Creative Enzymes | 1kg | EUR 324 |
Bevacizumab Lyophilized powder |
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| B077-5MG | TOKU-E | 5 mg | EUR 492 |
MEM Alpha Medium Powder |
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| 50-012-PC | Scientific Laboratory Supplies | EACH | EUR 82.08 |
5g G418 Sulphate powder |
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| 61-234-RG | Scientific Laboratory Supplies | EACH | EUR 421.2 |
100g MOPS Buffer Powder |
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| 46-103-RM | Scientific Laboratory Supplies | EACH | EUR 132.24 |
Iohexol (USP grade powder) |
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| 51R-U344600 | Fitzgerald | 200 mg | EUR 663.6 |
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Description: Iohexol (USP grade powder) chemical reference substance |
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Bottle Glass Powder 60Ml |
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| BP60C | Scientific Laboratory Supplies | PK72 | EUR 32.4 |
DMEM, High Glucose, Powder |
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| CMP01-001 | GenDepot | 10x1L | EUR 121.2 |
DMEM, High Glucose, Powder |
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| CMP01-010 | GenDepot | 10L | EUR 100.8 |
DMEM, High Glucose, Powder |
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| CMP01-050 | GenDepot | 50L | EUR 170.4 |
SSC Buffer Premix powder |
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| D0625 | Bio Basic | 1PK, 10L | EUR 73.57 |
9-OH Risperidone (powder) |
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| 50R-R76477 | Fitzgerald | 50 mg | EUR 159.6 |
|
Description: 9-OH Risperidone chemical reference substance |
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100g L-Glutamine Powder |
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| 61-030-RM | Scientific Laboratory Supplies | EACH | EUR 126.54 |
500g L-Glutamine Powder |
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| 61-030-RO | Scientific Laboratory Supplies | EACH | EUR 311.22 |
1000g L-Glutamine Powder |
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| 61-030-RR | Scientific Laboratory Supplies | EACH | EUR 213.18 |
Rifampin (USP grade powder) |
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| 51R-U604009 | Fitzgerald | 300 mg | EUR 619.2 |
|
Description: Rifampin (USP grade powder) chemical reference substance |
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Suprofen (USP grade powder) |
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| 51R-U642507 | Fitzgerald | 200 mg | EUR 619.2 |
|
Description: Suprofen (USP grade powder) chemical reference substance |
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Thiotepa (USP grade powder) |
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| 51R-U664000 | Fitzgerald | 500 mg | EUR 619.2 |
|
Description: Thiotepa (USP grade powder) chemical reference substance |
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Bottles Powder Clear 250ml |
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| BP250C | Scientific Laboratory Supplies | PK42 | EUR 24 |
Powder Bottles 30ml Clear |
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| BP30C80 | Scientific Laboratory Supplies | PK80 | EUR 30 |
Gibco Beef Extract Powder |
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| 212303 | Scientific Laboratory Supplies | EACH | EUR 208.9 |
Starch, powder, from potato |
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| GC9642-1KG | Glentham Life Sciences | 1 kg | EUR 84 |
Starch, powder, from potato |
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| GC9642-5KG | Glentham Life Sciences | 5 kg | EUR 204 |
Azaperone (USP grade powder) |
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| 51R-U04575-6 | Fitzgerald | 200 mg | EUR 619.2 |
|
Description: Azaperone (USP grade powder) chemical reference substance |
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Aztreonam (USP grade powder) |
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| 51R-U046205 | Fitzgerald | 200 mg | EUR 619.2 |
|
Description: Aztreonam (USP grade powder) chemical reference substance |
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Cefotetan (USP grade powder) |
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| 51R-U097975 | Fitzgerald | 500 mg | EUR 619.2 |
|
Description: Cefotetan (USP grade powder) chemical reference substance |
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Cefoxitin (USP grade powder) |
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| 51R-U098107 | Fitzgerald | 500 mg | EUR 624 |
|
Description: Cefoxitin (USP grade powder) chemical reference substance |
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Cisplatin (USP grade powder) |
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| 51R-U134357 | Fitzgerald | 100 mg | EUR 619.2 |
|
Description: Cisplatin (USP grade powder) chemical reference substance |
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Isoniazid (USP grade powder) |
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| 51R-U349706 | Fitzgerald | 200 mg | EUR 619.2 |
|
Description: Isoniazid (USP grade powder) chemical reference substance |
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Letrozole (USP grade powder) |
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| 51R-U356971 | Fitzgerald | 200 mg | EUR 603.6 |
|
Description: Letrozole (USP grade powder) chemical reference substance |
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Lidocaine (USP grade powder) |
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| 51R-U366002 | Fitzgerald | 250 mg | EUR 619.2 |
|
Description: Lidocaine (USP grade powder) chemical reference substance |
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Phenytoin (USP grade powder) |
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| 51R-U535008 | Fitzgerald | 200 mg | EUR 619.2 |
|
Description: Phenytoin (USP grade powder) chemical reference substance |
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Rifabutin (USP grade powder) |
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| 51R-U603800 | Fitzgerald | 50 mg | EUR 619.2 |
|
Description: Rifabutin (USP grade powder) chemical reference substance |
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Calf Thymus Acetone Powder |
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| E61A00101 | EnoGene | 5g | EUR 216 |
Calf Thymus Acetone Powder |
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| E61A00102 | EnoGene | 10g | EUR 333.6 |
Calf Thymus Acetone Powder |
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| E61A00103 | EnoGene | 100g | EUR 2400 |
Calf Spleen Acetone Powder |
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| E61A00201 | EnoGene | 5g | EUR 255.6 |
Calf Spleen Acetone Powder |
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| E61A00202 | EnoGene | 10g | EUR 372 |
Calf Spleen Acetone Powder |
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| E61A00203 | EnoGene | 100g | EUR 2790 |
Rabbit THYMUS ACETONE POWDER 100g |
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| 41008-2 | Pel-Freez | 100g | EUR 4529.35 |
1g Isopropylthiogalactoside Powder |
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| 46-102-RF | Scientific Laboratory Supplies | EACH | EUR 57.6 |
5g Kanamycin Sulfate Powder |
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| 61-176-RG | Scientific Laboratory Supplies | EACH | EUR 111.72 |
Ceforanide (USP grade powder) |
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| 51R-U097807 | Fitzgerald | 200 mg | EUR 619.2 |
|
Description: Ceforanide (USP grade powder) chemical reference substance |
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Cytarabine (USP grade powder) |
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| 51R-U162002 | Fitzgerald | 250 mg | EUR 619.2 |
|
Description: Cytarabine (USP grade powder) chemical reference substance |
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Gabapentin (USP grade powder) |
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| 51R-U287303 | Fitzgerald | 250 mg | EUR 619.2 |
|
Description: Gabapentin (USP grade powder) chemical reference substance |
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Lovastatin (USP grade powder) |
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| 51R-U370600 | Fitzgerald | 125 mg | EUR 528 |
|
Description: Lovastatin (USP grade powder) chemical reference substance |
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Zidovudine (USP grade powder) |
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| 51R-U724500 | Fitzgerald | 400 mg | EUR 619.2 |
|
Description: Zidovudine (USP grade powder) chemical reference substance |
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